Buccal films for the delivery of promethazine hydrochloride were fabricated using various film forming hydrophilic polymers, namely hydroxypropylmethyl cellulose, hydroxyethyl cellulose, sodium alginate and polyvinyl alcohol either alone or in combination with bioadhesive polymer sodium carboxymethyl cellulose. All the films prepared were smooth, elastic and homogenous in appearance. Various physicochemical parameters like weight uniformity, thickness, surface pH, folding endurance drug content, percentage moisture absorption and loss, tensile strength, swelling index, bioadhesive strength were evaluated. An in-vitro release study was carried out for 4 hours and all formulations obeyed first-order release kinetics. The sodium alginate polymer released maximum drug from the films owing to its erodible nature in presence of dissolution media. And it was concluded that optimum amount of bioadhesive polymer is required in the formulations for proper bioadhesion as well as controlled release from the formulations.
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